Macidol TR GAMMADOL® is a combination of ketorolaco and tramadol that is an analgesic indicated for the short-term treatment of moderate to severe acute pain (returned pain, fractures, dislocations, sprains, most cancers) in the treatment of postoperative ache, migraine, complications, and the treatment of neuropathic ache. The pharmacology of oral mixture analgesics rational treatment is for pain via distinct mechanisms of action, particularly an NSAID such as ketorolac and an opioid such as tramadol.
Macidol TR belongs to the group of NSAIDs and has been used in particular for its analgesic activity. Ketorolaco is a carboxylic acid pyrrolizine structurally related to indomethacin. Tramadol is a centrally acting analgesic with mechanisms of action that work synergistically to provide pain relief, and it has a low potential for abuse and dependence development when compared to other opioids. Both additives of the components are absorbed quickly and completely after oral administration.
The recommended tramadol dose is 50 to 100 mg (instant release drugs) every 4 to 6 hours as needed for pain relief.
The maximum daily dose is 400 mg.
Patients should begin at 25 mg/day to build tolerance, and doses can be increased by 25 to 50 mg every three days to reach 50 to one hundred mg/day every 4 to 6 hours.
The recommended dose for prolonged release tablets is one hundred mg per day, which can be increased by one hundred mg every five days, but not to exceed 300 mg/day. To convert from immediate release to extended release, the total daily dose should be rounded down to the nearest hundred mg. Extended-release capsules must be swallowed whole, without being beaten or chewed.
Tramadol can be taken with or without food.